Additional file 8 of Cancer-associated fibroblast-derived gene signatures determine prognosis in colon cancer patients

Additional file 8. CAF-related signatures showed stronger poor prognosis association in those patients with advanced colon tumors than in initial stages and in those patients with CMS4 than in CMS1–3. Comparison of the prognosis of the colon tumors (1235 samples) in initial stages I and II (660 samples) and in advanced stages III and IV (575 samples) (A), divided into CMS1–3 (593 samples) and CMS4 (237 samples) subtypes (B). The survival analysis used 2 gene signatures: the top 50 genes of the 67-gene signature (“CAF-derived exosomes signature”) and the top 50 of the 596-gene signature (“CAF signature”).