MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

3. HSP70 PROTEINS: CHAPERONES WITH DIVERSE ROLES IN PROTEIN METABOLISM . . .. . . . . . . . . .. . . . . .. . . ... . . . .... . . . . 357 Structure and Function of Hsp70 Chaperones . . . . . . . . . . . . . . . . . . . . . . . 357 Maintenance of the Translocation-Competent State of Precursor Proteins . . . . . . 359 The Hsp70 DnaK and Dna! are a Chaperone Team . . . . . . . . . . . . . . . . . . . 360 Organellar Hsp70s in Membrane Translocation and Folding .. . . . .. . . . . . . 361 Hsp70 in Cells Under Metabolic Stress . . . . . . . . . . . . . . . . . . . . . . . . . . . 362 Hsp70 and Protein Degradation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 363