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Effects of Fructus Ligustri Lucidi Extract on Bone Turnover and Calcium Balance in Ovariectomized Rats
- Source :
- Biological and Pharmaceutical Bulletin. 29:291-296
- Publication Year :
- 2006
- Publisher :
- Pharmaceutical Society of Japan, 2006.
-
Abstract
- The aim of this study was to evaluate the effect of Fructus Ligustri Lucidi (FLL), a kidney-tonifying Chinese herbal medicine, on the biochemical markers of bone turnover, calcium metabolism and balance in osteoporotic rat model developed by ovariectomy. Four weeks after surgical operation, animals were randomly assigned to one of the four treatments for 14 weeks: sham-operated control treated with vehicle (sham, n=8), ovariectomized group treated with vehicle (OVX, n=8), OVX group treated with 17beta-estradiol (E(2), n=10, 2 microg/kg/d) and OVX group treated with FLL extracts (FLL, n=10, 550 mg/kg/d). Serum osteocalcin and urinary deoxypyridinoline levels were upregulated in rats in response to OVX, suggesting that the bone turnover rate was accelerated in these animals. Treatment of OVX rats with FLL extract could prevent OVX-induced increase in bone turnover by suppression of both serum osteocalcin (p0.05, vs. OVX) and urinary deoxypyridinoline (p0.05, vs. OVX) levels. In addition, FLL extract could prevent OVX-induced loss of calcium in rats by increasing the intestinal calcium absorption rate (p0.01, vs. OVX), suppressing urinary Ca excretion (p0.05, vs. OVX) as well as increasing bone calcium content (p0.05, vs. OVX). Our study is the first to report that FLL can modulate bone turnover and calcium balance in OVX rats and it might be a potential candidate for prevention and treatment of postmenopausal osteoporosis.
- Subjects :
- endocrine system
medicine.medical_specialty
Deoxypyridinoline
Calcium balance
Ovariectomy
Urinary system
Ligustrum
Pharmaceutical Science
chemistry.chemical_element
Calcium
Bone and Bones
Bone remodeling
Rats, Sprague-Dawley
Excretion
chemistry.chemical_compound
Internal medicine
polycyclic compounds
medicine
Animals
Pharmacology
Calcium metabolism
Estradiol
General Medicine
Rats
Disease Models, Animal
surgical procedures, operative
Endocrinology
chemistry
Fruit
Ovariectomized rat
Osteoporosis
Female
Bone Remodeling
hormones, hormone substitutes, and hormone antagonists
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 13475215 and 09186158
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Biological and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....292507b33f676060f97b4f987264a800