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Three-day regimen of oseltamivir for postexposure prophylaxis of influenza in wards
- Source :
- Journal of hospital infection. 94(2):150-153
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- Inpatients who had been in close contact with patients with influenza were given oseltamivir [75 mg capsules once daily for adults or 2 mg/kg (maximum of 75 mg) once daily for children] for three days as postexposure prophylaxis (PEP). The index patients with influenza were prescribed a neuraminidase inhibitor and were discharged immediately or transferred to isolation rooms. The protective efficacy of oseltamivir for three days was 93% overall [95% confidence interval (CI) 53-99%; P = 0.023] and 94% for influenza A (95% CI 61-99%; P = 0.017), which is comparable to that of seven- to 10-day regimens of oseltamivir as PEP.
- Subjects :
- Adult
Male
Microbiology (medical)
medicine.medical_specialty
Oseltamivir
medicine.drug_class
medicine.medical_treatment
030501 epidemiology
Antiviral Agents
Chemoprevention
Post-exposure prophylaxis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Influenza, Human
medicine
Humans
030212 general & internal medicine
Close contact
Aged
Neuraminidase inhibitor
business.industry
virus diseases
Influenza a
General Medicine
Middle Aged
Postexposure prophylaxis
Virology
Confidence interval
Influenza
Regimen
Treatment Outcome
Infectious Diseases
chemistry
Female
Once daily
0305 other medical science
business
Subjects
Details
- Language :
- English
- ISSN :
- 01956701
- Volume :
- 94
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of hospital infection
- Accession number :
- edsair.doi.dedup.....29210e3eefa10727c296de2ba5995308