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Impaired Fibrin Formation in Advanced Cirrhosis
- Source :
- Pathophysiology of Haemostasis and Thrombosis. 6:137-148
- Publication Year :
- 1977
- Publisher :
- S. Karger AG, 1977.
-
Abstract
- The process of fibrin formation was systematically investigated in 25 patients with severe alcoholic cirrhosis. Results of functional tests are reported. A significant lengthening of the thrombin time was found which could not be completely attributed either to hypofibrinogenaemia or to an increase in physiological anticoagulants or to the presence of pathological antithrombins. A defect in fibrin polymerization was seen in the absence of significant levels of antipolymerizing agents. Indirect evidence pointed to an abnormal fibrinogen function. This was mainly suggested by the ‘polymerization curves’ of mixtures of normal and pathological plasmas and the changes in physico-chemical properties of the clot (optical and elastic properties; tensile strength). Altered synthesis in hepatocytes may lead to an ‘acquired dysfibrinogenaemia’ in the late stages of liver cirrhosis, although alteration of a normal fibrinogen molecule after secretion cannot be definitely excluded.
- Subjects :
- Adult
Liver Cirrhosis
medicine.medical_specialty
Pathology
Alcoholic liver disease
Time Factors
Polymers
Thrombin time
Gastroenterology
Fibrin
Physiology (medical)
Internal medicine
medicine
Humans
Dysfibrinogenaemia
Aged
biology
medicine.diagnostic_test
business.industry
Fibrinolysis
Advanced cirrhosis
Thrombin
Fibrinogen
Hematology
Middle Aged
medicine.disease
biology.protein
Blood Coagulation Tests
business
Subjects
Details
- ISSN :
- 14248840 and 14248832
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Pathophysiology of Haemostasis and Thrombosis
- Accession number :
- edsair.doi.dedup.....2920fb0d7ac436940fd6b0a54d83865d