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CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival
- Source :
- Neurology. 83:1945-1953
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- Objectives: We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis. Methods: We included 3,356 individuals with dementia who had CSF NFL analyzed in our laboratory between 2005 and 2012. Clinical diagnoses and Mini-Mental State Examination (MMSE) scores were obtained from the Swedish Dementia Registry, and in selected cases (n = 478), date of death from the Swedish Mortality Registry. Results: CSF NFL differed among clinical diagnoses, with the highest levels seen in frontotemporal dementia, VaD, and mixed AD and VaD. Early-onset AD (younger than 65 years) had the lowest levels. High CSF NFL correlated with low MMSE score and short survival time irrespective of diagnosis, and was also particularly evident in AD. Conclusions: CSF NFL differs among different neurodegenerative diseases and is especially high in dementias engaging subcortical brain regions, such as VaD and mixed AD and VaD, but also in frontotemporal dementia. The association of high CSF NFL levels with disease severity and short survival supports the notion that high CSF NFL levels indicate more aggressive disease processes.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Pathology
Neurology
Severity of Illness Index
Neurofilament Proteins
Predictive Value of Tests
Internal medicine
mental disorders
Severity of illness
medicine
Humans
Dementia
Registries
Amyotrophic lateral sclerosis
Vascular dementia
Aged
Aged, 80 and over
business.industry
Multiple sclerosis
Neurodegenerative Diseases
Middle Aged
medicine.disease
Survival Rate
Female
Neurology (clinical)
Alzheimer's disease
business
Biomarkers
Frontotemporal dementia
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....291d1bccd3b8119575d2f90e6d7da9d2