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Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 4770, p 4770 (2021)
- Publication Year :
- 2021
-
Abstract
- Mitochondria are key regulators of cell survival and are involved in a plethora of mechanisms, such as metabolism, Ca2+ signaling, reactive oxygen species (ROS) production, mitophagy and mitochondrial transfer, fusion, and fission (known as mitochondrial dynamics). The tuning of these processes in pathophysiological conditions is fundamental to the balance between cell death and survival. Indeed, ROS overproduction and mitochondrial Ca2+ overload are linked to the induction of apoptosis, while the impairment of mitochondrial dynamics and metabolism can have a double-faceted role in the decision between cell survival and death. Tumorigenesis involves an intricate series of cellular impairments not yet completely clarified, and a further level of complexity is added by the onset of apoptosis resistance mechanisms in cancer cells. In the majority of cases, cancer relapse or lack of responsiveness is related to the emergence of chemoresistance, which may be due to the cooperation of several cellular protection mechanisms, often mitochondria-related. With this review, we aim to critically report the current evidence on the relationship between mitochondria and cancer chemoresistance with a particular focus on the involvement of mitochondrial dynamics, mitochondrial Ca2+ signaling, oxidative stress, and metabolism to possibly identify new approaches or targets for overcoming cancer resistance.
- Subjects :
- Programmed cell death
QH301-705.5
Cell Survival
Antineoplastic Agents
Review
Mitochondrion
Biology
medicine.disease_cause
Mitochondrial Dynamics
Catalysis
NO
Inorganic Chemistry
Mitochondrial Proteins
mitochondrial dynamics, mitochondrial Ca2+ homeostasis, metabolic plasticity, drug resistance, cancer
Neoplasms
Mitophagy
medicine
Animals
Humans
cancer
Calcium Signaling
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Spectroscopy
drug resistance
Organic Chemistry
Cancer
General Medicine
medicine.disease
metabolic plasticity
Computer Science Applications
Cell biology
Mitochondria
mitochondrial Ca2+ homeostasis
Chemistry
Oxidative Stress
Apoptosis
Drug Resistance, Neoplasm
Cancer cell
Carcinogenesis
Oxidative stress
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....291af68ca967f7e6b7f70b4a4d3e748f