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Subcutaneous administration of a recombinant vaccinia virus vaccine expressing multiple envelopes of HIV-1
- Source :
- European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 23(2)
- Publication Year :
- 2004
-
Abstract
- A critical goal of HIV vaccine development is the identification of safe and immunogenic vectors. Recombinant vaccinia virus is a highly effective vaccine vector, with demonstrated capacity to protect animals from various viral pathogens, including rabies. Unlike many other candidate vaccine vectors, vast human experience exists with the parenteral smallpox vaccine. However, consideration of recombinant vaccinia virus as a modern vaccine is complicated by the relatively high prevalence of immunocompromised persons compared to such prevalence 4 or more decades ago (when smallpox vaccination was still routine). Administering vaccine by the subcutaneous (SQ) route, rather than the traditional scarification route, could address these concerns. SQ administration could prevent transmission of vaccinia virus to potentially vulnerable persons; it could also avoid the most common adverse events, which are cutaneous in nature. However, previous studies suggest that elicitation of immune response against passenger gene products following SQ administration requires development of a superficial pox lesion, defeating the intention of SQ administration. This is the first report to demonstrate that SQ administration of recombinant vaccinia virus does elicit immune response to the passenger protein in the absence of a cutaneous pox lesion. Results further show that a multi-envelope HIV vaccine can elicit antibody responses toward heterologous HIV-1 not represented by primary sequence in the vaccine. These findings have global implications because they support the consideration of recombinant vaccinia virus as a valuable HIV vaccine vector system.
- Subjects :
- Microbiology (medical)
Male
viruses
Injections, Subcutaneous
Enzyme-Linked Immunosorbent Assay
Vaccinia virus
Biology
Antibodies, Viral
Sensitivity and Specificity
Sampling Studies
HIV Envelope Protein gp160
chemistry.chemical_compound
Risk Factors
Humans
Orthopoxvirus
HIV vaccine
Smallpox vaccine
Duck embryo vaccine
Vaccines, Synthetic
Attenuated vaccine
Viral Vaccine
ACAM2000
Viral Vaccines
General Medicine
Viral Load
biology.organism_classification
Virology
Infectious Diseases
chemistry
Immunology
Female
Vaccinia
Subjects
Details
- ISSN :
- 09349723
- Volume :
- 23
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....290b77676a4eb998f94b1915dcc9ab7e