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Serially Ordered Magnetization of Nanoclusters via Control of Various Transition Metal Dopants for the Multifractionation of Cells in Microfluidic Magnetophoresis Devices
- Source :
- Analytical Chemistry. 88:1078-1082
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- A novel method (i.e., continuous magnetic cell separation in a microfluidic channel) is demonstrated to be capable of inducing multifractionation of mixed cell suspensions into multiple outlet fractions. Here, multicomponent cell separation is performed with three different distinguishable magnetic nanoclusters (MnFe2O4, Fe3O4, and CoFe2O4), which are tagged on A431 cells. Because of their mass magnetizations, which can be ideally altered by doping with magnetic atom compositions (Mn, Fe, and Co), the trajectories of cells with each magnetic nanocluster in a flow are shown to be distinct when dragged under the same external magnetic field; the rest of the magnetic characteristics of the nanoclusters are identically fixed. This proof of concept study, which utilizes the magnetization-controlled nanoclusters (NCs), suggests that precise and effective multifractionation is achievable with high-throughput and systematic accuracy for dynamic cell separation.
- Subjects :
- Surface Properties
Microfluidics
Analytical chemistry
Cell Separation
02 engineering and technology
01 natural sciences
Analytical Chemistry
Nanoclusters
Magnetization
Cell Line, Tumor
Atom
Transition Elements
Physics::Atomic and Molecular Clusters
Humans
Particle Size
Magnetite Nanoparticles
Dopant
Chemistry
Magnetic Phenomena
010401 analytical chemistry
Doping
Microfluidic Analytical Techniques
021001 nanoscience & nanotechnology
0104 chemical sciences
Magnetic field
Chemical physics
0210 nano-technology
Subjects
Details
- ISSN :
- 15206882 and 00032700
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Analytical Chemistry
- Accession number :
- edsair.doi.dedup.....290926ccf8dcaa7b6d788c1979d711ab