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Use of Parenteral Colistin for the Treatment of Serious Infection Due to Antimicrobial-Resistant Pseudomonas aeruginosa
- Source :
- Scopus-Elsevier
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- Serious infection due to strains of Pseudomonas aeruginosa that exhibit resistance to all common antipseudomonal antimicrobials increasingly is a serious problem. Colistin was used as salvage therapy for 23 critically ill patients with multidrug-resistant P. aeruginosa infection. Twenty-two patients who had septic shock (n=14) and/or renal failure (n=21) received mechanical ventilatory support at baseline. The most common types of infection were pneumonia (n=18) and intra-abdominal infection (n=5). Colistin was administered for a median of 17 days (range, 7-36 days). Seven patients died during therapy, at a median of 17 days (range, 4-26 days) after initiation of treatment. A favorable clinical response was observed in 14 patients (61%); only 3 patients experienced relapse. Bacteremia was the only significant factor associated with treatment failure (P=.02). One patient manifested diffuse weakness that resolved after temporary cessation of colistin therapy. Colistin provides an important salvage therapeutic option for patients with otherwise untreatable serious P. aeruginosa infection.
- Subjects :
- Adult
Male
Microbiology (medical)
medicine.medical_specialty
Salvage therapy
Microbial Sensitivity Tests
Drug resistance
medicine.disease_cause
Internal medicine
medicine
Humans
Infusions, Parenteral
Pseudomonas Infections
Aged
Salvage Therapy
Colistin
business.industry
Septic shock
Pseudomonas aeruginosa
Ventilator-associated pneumonia
Drug Resistance, Microbial
Middle Aged
medicine.disease
Anti-Bacterial Agents
Surgery
Intensive Care Units
Pneumonia
Treatment Outcome
Infectious Diseases
Bacteremia
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....28e7b27f07de0f1ba821242b01bcc4b5