Back to Search
Start Over
Neuroleukemiosis: Diagnosis and management
- Source :
- Clinical neurology and neurosurgery. 184
- Publication Year :
- 2018
-
Abstract
- An exceedingly rare manifestation of leukemia, termed neuroleukemiosis, involves peripheral nerve infiltration by leukemic cells. Patients with neuroleukemiosis typically present with a peripheral neuropathy and/or chloromatous masses. The diagnosis is supported by, and established with, electrophysiologic testing, imaging, histopathology, and immunophenotyping. We present the case of 21 year old male with multiply relapsed M4 type of acute myelogenous leukemia (AML) who presented with extremity pain and was subsequently found to have multiple cervical, thoracic, and lumbosacral nerve root masses. A diagnosis of neuroleukemiosis was established via CT-guided biopsy and immunophenotyping. The patient's neuroleukemiosis responded well to chemotherapy, donor lymphocyte infusions, and spinal irradiation. The literature is reviewed regarding this interesting and rare clinical condition.
- Subjects :
- Male
medicine.medical_specialty
Nerve root
03 medical and health sciences
Myelogenous
Young Adult
0302 clinical medicine
Immunophenotyping
Biopsy
medicine
Humans
medicine.diagnostic_test
business.industry
Disease Management
Peripheral Nervous System Diseases
General Medicine
medicine.disease
Leukemia
Leukemia, Myeloid, Acute
Peripheral neuropathy
030220 oncology & carcinogenesis
Surgery
Histopathology
Neurology (clinical)
Radiology
business
030217 neurology & neurosurgery
Lumbosacral joint
Subjects
Details
- ISSN :
- 18726968
- Volume :
- 184
- Database :
- OpenAIRE
- Journal :
- Clinical neurology and neurosurgery
- Accession number :
- edsair.doi.dedup.....28e4edb16a57aaea1ca8b3d5d7aea383