Back to Search
Start Over
Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici
- Source :
- Lamour, Kurt H.; Mudge, Joann; Gobena, Daniel; Hurtado-Gonzales, Oscar P.; Schmutz, Jeremy; Kuo, Alan; et al.(2012). Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici. Molecular Plant Microbe Interactions. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/5rw79183, Molecular Plant-Microbe Interactions, Molecular Plant-Microbe Interactions, American Phytopathological Society, 2012, 25 (10), pp.1350-60. ⟨10.1094/MPMI-02-12-0028-R⟩
- Publication Year :
- 2012
- Publisher :
- eScholarship, University of California, 2012.
-
Abstract
- The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually-recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic/genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) and higher levels of SNVs than those reported for humans, plants, and P. infestans. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting >30% of the genome. LOH altered genotypes for more than 11,000 single nucleotide variant (SNV) sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici.
- Subjects :
- 0106 biological sciences
Phytophthora
Genotype
Physiology
Genetic Linkage
Outcrossing
champignon pathogène
Biology
01 natural sciences
Genome
Polymorphism, Single Nucleotide
Article
Loss of heterozygosity
03 medical and health sciences
Cucurbita
Genetic variation
protection des plantes
[SDV.BV]Life Sciences [q-bio]/Vegetal Biology
fungal pathogen
030304 developmental biology
Plant Diseases
2. Zero hunger
Oomycete
Genetics
0303 health sciences
fungi
Chromosome Mapping
General Medicine
biology.organism_classification
Adaptation, Physiological
Phytophthora capsici
Gene Expression Regulation
Capsicum
Agronomy and Crop Science
phytophthora capsici
010606 plant biology & botany
crop protection
Subjects
Details
- Language :
- English
- ISSN :
- 08940282
- Database :
- OpenAIRE
- Journal :
- Lamour, Kurt H.; Mudge, Joann; Gobena, Daniel; Hurtado-Gonzales, Oscar P.; Schmutz, Jeremy; Kuo, Alan; et al.(2012). Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici. Molecular Plant Microbe Interactions. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/5rw79183, Molecular Plant-Microbe Interactions, Molecular Plant-Microbe Interactions, American Phytopathological Society, 2012, 25 (10), pp.1350-60. ⟨10.1094/MPMI-02-12-0028-R⟩
- Accession number :
- edsair.doi.dedup.....28e1bc8da5cdc4a105079deca2cc3b83