Back to Search
Start Over
Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma
- Source :
- Environment International, Vol 137, Iss, Pp-(2020)
- Publication Year :
- 2019
-
Abstract
- Perfluoroalkyl (PFAS) substances are widespread in the environment and in organisms. The fact that exposure to PFAS is associated with elevated cholesterol levels is a major concern for human health. Previous investigations, in which bovine serum albumin was frequently studied, indicate that PFOS, PFOA and PFNA bind to serum albumin. However, it is critical to know whether these and other PFAS have a preference for the protein or the lipid fraction in native human blood fractions. For this reason, blood samples from four young healthy volunteers (two women, two men, 23–31 years old) were used for protein size separation and fractionation by the Cohn method in combination with serial ultracentrifugation. The plasma fractions were analyzed for 11 PFAS using high-performance tandem mass spectrometry (HPLC-MS/MS). Although the data are based on a small sample, they clearly show that albumin is the most important carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in native human plasma. These five compounds have very little or no affinity for lipoproteins. The confirmation of their transport through albumin is important for the epidemiology of PFAS. The present results must be verified by the examination of a larger number of persons. Keywords: Albumin, Human plasma, perfluoroalkyl substances (PFAS)
- Subjects :
- Adult
Male
medicine.medical_specialty
010504 meteorology & atmospheric sciences
Lipoproteins
Serum albumin
Fractionation
010501 environmental sciences
Tandem mass spectrometry
01 natural sciences
chemistry.chemical_compound
Young Adult
Tandem Mass Spectrometry
Internal medicine
Albumins
medicine
Humans
Bovine serum albumin
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
lcsh:GE1-350
Fluorocarbons
biology
Chemistry
Cholesterol
Albumin
Lipids
Endocrinology
Alkanesulfonic Acids
Human plasma
Carrier protein
biology.protein
Environmental Pollutants
Female
Subjects
Details
- ISSN :
- 18736750
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Environment international
- Accession number :
- edsair.doi.dedup.....28e141c193685265a8f8d8e5d89296c0