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Anti-breast cancer triterpenoid saponins from the thorns of Gleditsia sinensis
- Source :
- Natural Product Research. 33:2308-2313
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- One new triterpenoid saponin (1), as well as six known ones (2–7), were isolated from the ethanol extract of the thorns of Gleditsia sinensis. Their structures were elucidated by extensive spectroscopic analysis in conjunction with chemical evidence. Cytotoxic activity of compounds 1–6 was evaluated against human breast cancer MCF 7 cells in vitro by the MTT method. Our results revealed moderate activities for compounds 1–6 with IC50 values of 18.43, 30.47, 18.46, 10.02, 30.76, and 17.32 μM, respectively. Furthermore, compounds 1, 3, 4, and 6 induced apoptosis in MCF 7 cell, with 1 and 6 causing late apoptosis of MCF 7 cells, while 3 and 4 acting oppositely.
- Subjects :
- chemistry.chemical_classification
biology
Traditional medicine
010405 organic chemistry
Anti breast cancer
Organic Chemistry
Plant Science
biology.organism_classification
01 natural sciences
Biochemistry
0104 chemical sciences
Analytical Chemistry
Gleditsia sinensis
010404 medicinal & biomolecular chemistry
Triterpenoid
chemistry
Triterpenoid saponin
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi.dedup.....28d8986b7f6ab0a770d251b7a2541eda