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Mouse phenogenomics: the fast track to 'systems metabolism'
- Source :
- Cell Metabolism, Cell Metabolism, Elsevier, 2005, 2 (6), pp.349-60. ⟨10.1016/j.cmet.2005.11.002⟩
- Publication Year :
- 2005
-
Abstract
- With the completion of the many genomes, genetics is positioned to meet physiology. In this review, we summarize the coming of "systems metabolism" in mammals through the use of the mouse, as a model system to study metabolism. Building on mouse genetics with increasingly sophisticated clinical and molecular phenotyping strategies has enabled scientists to now tackle complex biomedical questions, such as those related to the pathogenesis of the common metabolic disorders. The ultimate goal of such strategies will be to mimic human metabolism with the click of a mouse.
- Subjects :
- Physiology
Systems biology
MESH: Pharmacogenetics
Human metabolism
Genomics
Model system
Computational biology
Biology
MESH: Phenotype
Bioinformatics
Genome
Models, Biological
Chromosomes
03 medical and health sciences
Mice
0302 clinical medicine
MESH: Computer Simulation
Animals
Humans
MESH: Animals
MESH: Genome
Computer Simulation
MESH: Models, Genetic
MESH: Mice
Molecular Biology
Crosses, Genetic
030304 developmental biology
0303 health sciences
MESH: Humans
Models, Genetic
Extramural
MESH: Genomics
Systems Biology
MESH: Models, Biological
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
Cell Biology
MESH: Crosses, Genetic
Phenotype
Pharmacogenetics
MESH: Systems Biology
MESH: Genetic Engineering
MESH: Chromosomes
Genetic Engineering
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15504131
- Volume :
- 2
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cell metabolism
- Accession number :
- edsair.doi.dedup.....28d7639f289fea1c108d3f0a9ea1316c