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Pre-operative liver biopsy in cirrhotic patients with early hepatocellular carcinoma represents a safe and accurate diagnostic tool for tumour grading assessment
- Source :
- Journal of hepatology. 54(2)
- Publication Year :
- 2010
-
Abstract
- BACKGROUND & AIMS: Knowledge of pre-operative tumour grade is crucial in the management of hepatocellular carcinoma (HCC) because it can influence recurrence and survival after surgery. The accuracy of pre-operative needle core biopsy (NCB) in tumour grading has been assessed in only a few studies with conflicting results. Our aim was to determine the long-term safety and the overall accuracy of NCB in assessing tumour grading in subjects who had undergone liver resection for a single HCC. METHODS: Eighty-one cirrhotic patients with HCC who had undergone NCB before liver resection were selected. Only patients with a single HCC and with at least a five-year-follow-up were included. Tumour grading was scored according to a modified Edmondson-Steiner classification: well/moderately (low grade) vs poorly-differentiated (high grade). RESULTS: In the 81 patients with a solitary HCC (mean size 4.1 ± 2.3cm) tumour grade was correctly identified by NCB in 74 out of 81 (91.4%) HCCs. NCB overall sensitivity and specificity were 65% and 98.1%, respectively, with a PPV of 92% and an NPV of 91%. No major complications (in particular tumour seeding) were observed. The overall survival rates at 1, 3, and 5 years were 83%, 62%, and 44%, respectively; the recurrence rate after a 5-year-follow-up was 56.2% for low grade and 82.3% for high grade tumours (p
- Subjects :
- Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Carcinoma, Hepatocellular
HEPATOCELLULAR CARCINOMA
LIVER NEOPLASMS
Needle Biopsy
NEOPLASM STAGING
Hepatocellular carcinoma
medicine.medical_treatment
Liver transplantation
Gastroenterology
NO
Liver resection, Liver transplantation, Hepatocellular carcinoma, Liver cirrhosis, Liver biopsy
Internal medicine
Biopsy
Carcinoma
Medicine
Early Hepatocellular Carcinoma
Humans
Aged
Neoplasm Staging
Hepatology
medicine.diagnostic_test
Liver resection
business.industry
Biopsy, Needle
Liver Neoplasms
Liver biopsy
Middle Aged
medicine.disease
Liver
Female
Hepatectomy
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 16000641
- Volume :
- 54
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of hepatology
- Accession number :
- edsair.doi.dedup.....28d569bdd37f7f0474e45418ef4129c5