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Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity
- Source :
- World Journal of Diabetes
- Publication Year :
- 2021
- Publisher :
- Baishideng Publishing Group Inc, 2021.
-
Abstract
- BACKGROUND Diabetes is a common chronic disease. Given the increasing incidence of diabetes, more individuals are affected by diabetic optic neuropathy (DON), which results in decreased vision. Whether DON leads to abnormalities of other visual systems, including the eye, the visual cortex, and other brain regions, remains unknown. AIM To investigate the local characteristics of spontaneous brain activity using regional homogeneity (ReHo) in patients with DON. METHODS We matched 22 patients with DON with 22 healthy controls (HCs). All subjects underwent resting-state functional magnetic resonance imaging. The ReHo technique was used to record spontaneous changes in brain activity. Receiver operating characteristic (ROC) curves were applied to differentiate between ReHo values for patients with DON and HCs. We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis. RESULTS ReHo values of the right middle frontal gyrus (RMFG), left anterior cingulate (LAC), and superior frontal gyrus (SFG)/left frontal superior orbital gyrus (LFSO) were significantly lower in DON patients compared to HCs. Among these, the greatest difference was observed in the RMFG. The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON, and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO. We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values (r = -0.9336, P < 0.0001 and r = -0.8453, P < 0.0001, respectively). CONCLUSION Three different brain regions show ReHo changes in DON patients, and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients.
- Subjects :
- Brain activity and meditation
Endocrinology, Diabetes and Metabolism
Diabetic optic neuropathy
Functional magnetic resonance imaging
Clinical Trials Study
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Regional homogeneity
Optic neuropathy
03 medical and health sciences
0302 clinical medicine
Nuclear magnetic resonance
Diabetes mellitus
Internal Medicine
Medicine
In patient
Resting state
medicine.diagnostic_test
Resting state fMRI
business.industry
Homogeneity (statistics)
Diabetes
equipment and supplies
medicine.disease
Resting state functional magnetic resonance imaging
business
Brain activity
human activities
Subjects
Details
- Language :
- English
- ISSN :
- 19489358
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- World Journal of Diabetes
- Accession number :
- edsair.doi.dedup.....28d12c7659ba3752469f73c99e693920