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Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice
- Source :
- European journal of pharmacology. 366(2-3)
- Publication Year :
- 1999
-
Abstract
- The immunomodulatory effects of dihydroetorphine were systematically investigated in subchronically treated mice. In a dose-dependent fashion, dihydroetorphine (total doses at 444.5, 889 and 1778 μg/kg) lowered the increase of body weight, decreased the weight of the spleen and thymus, weakened the delayed-type hypersensitivity, reduced the generation of antibody-forming cells, inhibited splenic lymphocyte proliferation induced by concanavalin A and lipopolysaccharide, suppressed the production of interleukin-2 in the supernatant of splenocytes induced by concanavalin A, and depleted the ratio of CD4 + and CD8 + subpopulations. Moreover, the physical dependence on dihydroetorphine was also evaluated to confirm that the immunosuppression was concomitant with the addiction to the drug. These results demonstrate that subchronic treatment with dihydroetorphine dose dependently suppresses both humoral and cell-mediated immune function, and that the immunosuppressive effects of dihydroetorphine are much more potent than those of morphine.
- Subjects :
- Dihydroetorphine
Lipopolysaccharide
Physical dependence
Thymus Gland
Pharmacology
chemistry.chemical_compound
Mice
Immune system
Splenocyte
medicine
Animals
Hypersensitivity, Delayed
Lymphocyte Count
Lymphocytes
Antibody-Producing Cells
Lymphokines
biology
Dose-Response Relationship, Drug
business.industry
Naloxone
Body Weight
Etorphine
Organ Size
Opioid-Related Disorders
Lymphocyte Subsets
Substance Withdrawal Syndrome
Analgesics, Opioid
Mice, Inbred C57BL
chemistry
Concanavalin A
Toxicity
Immunology
Morphine
biology.protein
Female
medicine.symptom
business
Cell Division
Immunosuppressive Agents
Spleen
medicine.drug
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 366
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....28c7792b267d1216bbfffb6adb9b2583