Back to Search
Start Over
Conessine, an H3 receptor antagonist, alters behavioral and neurochemical effects of ethanol in mice
- Source :
- Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP
- Publication Year :
- 2015
-
Abstract
- Made available in DSpace on 2018-12-11T16:41:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-05-15 Ethanol abuse potential is mainly due to its reinforcing properties, crucial in the transition from the recreational to pathological use. These properties are mediated by mesocorticolimbic and nigrostriatal dopaminergic pathways and neuroadaptations in these pathways seem to be responsible for addiction. Both pathways are modulated by other neurotransmitters systems, including neuronal histaminergic system. Among the histamine receptors, H3 receptor stands out due to its role in modulation of histamine and other neurotransmitters release. Thus, histaminergic system, through H3 receptors, may have an important role in ethanol addiction development. Aiming to understand these interactions, conessine, an H3 receptor antagonist, was given to mice subjected to the evaluation of ethanol-induced psychostimulation, ethanol CPP and quantification of norepinephrine, dopamine, serotonin and their metabolites in mesocorticolimbic and nigrostriatal pathways following acute ethanol treatment. Systemic conessine administration exacerbated ethanol effects on locomotor activity. Despite of conessine reinforcing effect on CPP, this drug did not alter acquisition of ethanol CPP. Ethanol treatment affects the serotoninergic neurotransmission in the ventral tegmental area, the dopaminergic neurotransmission in the pre-frontal cortex (PFC) and caudate-putamen nucleus (CPu) and the noradrenergic neurotransmission in the CPu. In the PFC, conessine blocked ethanol effects on dopaminergic and noradrenergic neurotransmission. The blockade of H3 receptors and ethanol seem to interact in the modulation of dopaminergic neurotransmission of nigrostriatal pathway, decreasing dopamine metabolites in substantia nigra. In conclusion, conessine was able to change psychostimulant effect of ethanol, without altering its reinforcing properties. This exacerbation of ethanol-induced psychostimulation would be related to alterations in dopaminergic neurotransmission in the nigrostriatal pathway. Laboratory of Pharmacology School of Pharmaceutical Sciences Univ Estadual Paulista-UNESP Joint Graduate Program in Physiological Sciences UFSCar/UNESP Institute of Biomedical Sciences Federal University of Uberlândia (UFU) Laboratory of Pharmacology School of Pharmaceutical Sciences Univ Estadual Paulista-UNESP Joint Graduate Program in Physiological Sciences UFSCar/UNESP
- Subjects :
- 0301 basic medicine
Monoamines
Male
Alcohol addiction
Nigrostriatal pathway
Pharmacology
Neurotransmission
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
Mice
0302 clinical medicine
Alkaloids
Dopamine
medicine
Animals
Chromatography, High Pressure Liquid
Analysis of Variance
Neurotransmitter Agents
Dose-Response Relationship, Drug
Ethanol
Conessine
Dopaminergic
Brain
Central Nervous System Depressants
Homovanillic Acid
Conditioned place preference
Ventral tegmental area
Psychostimulation
030104 developmental biology
medicine.anatomical_structure
H3 receptor antagonist
chemistry
Dopaminergic pathways
3,4-Dihydroxyphenylacetic Acid
Conditioning, Operant
Neuroscience
030217 neurology & neurosurgery
Locomotion
medicine.drug
Histamine H3 Antagonists
Subjects
Details
- ISSN :
- 18727549
- Volume :
- 305
- Database :
- OpenAIRE
- Journal :
- Behavioural brain research
- Accession number :
- edsair.doi.dedup.....28c53ef43352ff13b62bacdf689c8f86