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Striatal bilateral control of skilled forelimb movement
- Source :
- Cell reports. 34(3)
- Publication Year :
- 2018
-
Abstract
- Summary Skilled motor behavior requires bihemispheric coordination, and participation of striatal outputs originating from two neuronal groups identified by distinctive expression of D1 or D2 dopamine receptors. We trained mice to reach for and grasp a single food pellet and determined how the output pathways differently affected forelimb trajectory and task efficiency. We found that inhibition and excitation of D1-expressing spiny projection neurons (D1SPNs) have a similar effect on kinematics results, as if excitation and inhibition disrupt the whole ensemble dynamics and not exclusively one kind of output. In contrast, D2SPNs participate in control of target accuracy. Further, ex vivo electrophysiological comparison of naive mice and mice exposed to the task showed stronger striatal neuronal connectivity for ipsilateral D1 and contralateral D2 neurons in relation to the paw used. In summary, while the output pathways work together to smoothly execute skill movements, practice of the movement itself changes synaptic patterns.
- Subjects :
- 0301 basic medicine
Movement
Striatum
Biology
Optogenetics
Medium spiny neuron
Indirect pathway of movement
General Biochemistry, Genetics and Molecular Biology
Corpus Striatum
03 medical and health sciences
Electrophysiology
Mice
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Forelimb
medicine
Animals
Direct pathway of movement
Motor learning
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 34
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cell reports
- Accession number :
- edsair.doi.dedup.....28b253d176e4557eaa36f9311d7b771e