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123I-metaiodobenzylguanidine myocardial scintigraphy with early images alone is useful for the differential diagnosis of dementia with Lewy bodies
- Source :
- Psychiatry research. Neuroimaging. 261
- Publication Year :
- 2016
-
Abstract
- 123I-metaiodobenzylguanidine cardiac scintigraphy (MIBG) is a useful imaging technique for the diagnosis of dementia with Lewy bodies (DLB). However, MIBG has a serious disadvantage in that it demands a long examination time. The objective of this study was to evaluate statistically the usefulness of the heart/mediastinum ratio (H/M) from the early phase of MIBG for the differential diagnosis of DLB. In total, 113 patients were examined, including 32 non-DLB (19 with Alzheimer's dementia) and 79 DLB patients. The mean early-H/M ratio was 2.83 in the non-DLB group and 1.95 in the DLB group. The mean delayed-H/M ratio was 3.0 in the non-DLB group and 1.76 in the DLB group. With a cutoff point of 2.27 on early images, the sensitivity, specificity, and diagnostic accuracy were 65%, 94%, and 73%, respectively, and the area under the curve was 0.82, indicating moderate accuracy. This analysis indicates that images from the early phase of MIBG alone are sufficient for the differential diagnosis of Alzheimer's disease and DLB.
- Subjects :
- Lewy Body Disease
Male
Pathology
medicine.medical_specialty
Parkinson's disease
Neuroscience (miscellaneous)
behavioral disciplines and activities
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Myocardial scintigraphy
Alzheimer Disease
mental disorders
medicine
Dementia
Humans
Radiology, Nuclear Medicine and imaging
Aged
Aged, 80 and over
Dementia with Lewy bodies
123i mibg
Area under the curve
Myocardial Perfusion Imaging
Mediastinum
Heart
Middle Aged
medicine.disease
nervous system diseases
Psychiatry and Mental health
3-Iodobenzylguanidine
medicine.anatomical_structure
nervous system
Female
Radiology
Differential diagnosis
Radiopharmaceuticals
Psychology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18727506
- Volume :
- 261
- Database :
- OpenAIRE
- Journal :
- Psychiatry research. Neuroimaging
- Accession number :
- edsair.doi.dedup.....28b05b5d34a5d3fbe89d200fba3f297f