Back to Search
Start Over
The piriform, perirhinal, and entorhinal cortex in seizure generation
- Source :
- Frontiers in Neural Circuits, Frontiers in Neural Circuits, Vol 9 (2015)
- Publication Year :
- 2015
- Publisher :
- Frontiers Media SA, 2015.
-
Abstract
- Understanding neural network behavior is essential to shed light on epileptogenesis and seizure propagation. The interconnectivity and plasticity of the limbic and cortical regions of the mammalian brain provide the substrate for the hypersynchrony and hyperexcitability associated with epilepsy and seizure activity. Recurrent unprovoked seizures are the hallmark of epilepsy, and limbic epilepsy is the most common type of medically-intractable focal epilepsy in adolescents and adults that necessitates surgical evaluation. In this review, we describe the role and relationships among the piriform (PIRC), perirhinal (PRC), and entorhinal cortex (ERC) in seizure-generation and epilepsy. The inherent function, anatomy, and histological composition of these cortical regions are discussed. In addition, the neurotransmitters, intrinsic and extrinsic connections, and the interaction of these regions are described. Furthermore, we provide evidence based on clinical research and animal models that suggest that these cortical regions may act as key seizure-trigger zones and, even, epileptogenesis.
- Subjects :
- Nerve net
Cognitive Neuroscience
Neuroscience (miscellaneous)
Piriform Cortex
Review
Biology
Epileptogenesis
lcsh:RC321-571
Temporal lobe
Cellular and Molecular Neuroscience
Epilepsy
Seizures
Piriform cortex
Perirhinal cortex
medicine
Animals
Humans
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Limbic epilepsy
entorhinal cortex
perirhinal cortex
temporal lobe epilepsy
Entorhinal cortex
medicine.disease
Temporal Lobe
Sensory Systems
medicine.anatomical_structure
epileptogenesis
Nerve Net
Neuroscience
area tempestas
Subjects
Details
- ISSN :
- 16625110
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neural Circuits
- Accession number :
- edsair.doi.dedup.....28addd9dad3a65beabe7b077d49d3453
- Full Text :
- https://doi.org/10.3389/fncir.2015.00027