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Microscopic colitis in patients with Takayasu's arteritis: a potential association between the two disease entities
- Source :
- Clinical rheumatology. 35(10)
- Publication Year :
- 2015
-
Abstract
- The association of Takayasu’s arteritis (TAK) and inflammatory bowel disease (IBD) has previously been reported in case series. Microscopic colitis (MC) has IBD-like symptoms with regard to clinical and histopathological feature. We aim to assess the presence of MC in TAK patients in this study. We cross-sectionally assessed TAK patients, between the ages of 18–65 years, who were diagnosed according to the American College of Rheumatology (ACR) criteria. Disease activity was evaluated by Kerr’s criteria. Age- and sex-matched irritable bowel syndrome (IBS) patients were selected as control group. All patients and controls have been interviewed for IBD and IBS symptoms using the questionnaires of WHO guideline and Rome III criteria, respectively. Lower endoscopic procedure was performed with at least five random biopsies taken from different colonic segments and the terminal ileum. A blinded expert pathologist evaluated the specimens for the features of MC. Thirty TAK patients (29 females and 1 male) with the mean age of 35 ± 11 years (range, 20–59 years) and 15 IBS controls with the mean age of 38 ± 13 years were included in the study. TAK patients all fulfilled the MC criteria (three “complete” and six “incomplete” cases). MC was found to be significantly higher in active TAK patients in comparison to inactive group (67 vs 14 %, p = 0.03, OR = 7.9). Our results show that there is an increased frequency of MC in TAK patients, and this is the first report on the association of TAK and MC.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Colon
Takayasu's arteritis
Disease
Inflammatory bowel disease
Gastroenterology
03 medical and health sciences
Young Adult
0302 clinical medicine
Microscopic colitis
Rheumatology
Ileum
Internal medicine
Medicine
Humans
Arteritis
Irritable bowel syndrome
030203 arthritis & rheumatology
business.industry
General Medicine
Guideline
Middle Aged
medicine.disease
Takayasu Arteritis
Colitis, Microscopic
Cross-Sectional Studies
030211 gastroenterology & hepatology
Female
business
Subjects
Details
- ISSN :
- 14349949
- Volume :
- 35
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical rheumatology
- Accession number :
- edsair.doi.dedup.....28aaefdac11d920d7693773bd3222fbc