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Prenatal Management of Congenital Human Cytomegalovirus Infection in Seropositive Pregnant Patients Treated with Azathioprine
- Source :
- Diagnostics, Vol 10, Iss 542, p 542 (2020), Diagnostics
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Human cytomegalovirus (HCMV) is the leading infectious agent causing congenital disabilities. The risk of HCMV transmission to the fetus in pregnant women receiving immunosuppressive agents is unknown. We describe two cases of pregnant women with evidence of pre-conception HCMV protective immunity receiving azathioprine for ulcerative colitis or systemic lupus erythematosus. Both women reactivated the HCMV and transmitted the infection to the fetuses. One newborn showed unilateral hearing deficits and brain abnormalities while the other was asymptomatic. The mother of the symptomatic newborn had low levels of total and HCMV-specific blood CD4+ T cells. Women receiving immunosuppressive agents deserve information about the risk of HCMV congenital infection and should be monitored for HCMV infection during pregnancy. Their newborns should be screened for HCMV congenital infection.
- Subjects :
- 0301 basic medicine
Ganciclovir
Human cytomegalovirus
Fetal MRI
viruses
Clinical Biochemistry
Azathioprine
Case Report
Asymptomatic
Serology
congenital cytomegalovirus infection
03 medical and health sciences
0302 clinical medicine
fetal MRI
Pregnancy
Ultrasound
medicine
Congenital cytomegalovirus infection
lcsh:R5-920
030219 obstetrics & reproductive medicine
azathioprine
business.industry
ultrasound
virus diseases
Valganciclovir
biochemical phenomena, metabolism, and nutrition
medicine.disease
Ulcerative colitis
030104 developmental biology
Immunology
pregnancy
medicine.symptom
business
lcsh:Medicine (General)
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 10
- Issue :
- 542
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....28a098d1df60637b6e09764b3f252be5