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Structure and unique mechanical aspects of nuclear lamin filaments
- Source :
- Current Opinion in Structural Biology. 64:152-159
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The major constituent of the nuclear envelope is the nuclear lamina. A fibrous meshwork of lamin filaments spanning underneath the nuclear membrane provides mechanical support to the nucleus. Lamins, type V intermediate filament proteins, are also involved in many other nuclear activities such as DNA repair and transcription. Recent structural studies provide new insight into how lamins assemble into ∼3.5nm thick filaments, which is in contrast with cytoplasmic intermediate filaments. The thinnest component of the cell cytoskeleton exhibits surprising mechanical properties. Here, we critically review and discuss structural and mechanical aspects of single lamin filaments.
- Subjects :
- Nuclear Envelope
DNA repair
Intermediate Filaments
610 Medicine & health
macromolecular substances
03 medical and health sciences
1315 Structural Biology
0302 clinical medicine
Structural Biology
10019 Department of Biochemistry
1312 Molecular Biology
medicine
Nuclear membrane
Cytoskeleton
Intermediate filament
Molecular Biology
030304 developmental biology
Cell Nucleus
0303 health sciences
Nuclear Lamina
Chemistry
Lamins
medicine.anatomical_structure
Cytoplasm
Biophysics
570 Life sciences
biology
Nuclear lamina
Nucleus
030217 neurology & neurosurgery
Lamin
Subjects
Details
- ISSN :
- 0959440X
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Structural Biology
- Accession number :
- edsair.doi.dedup.....289ef3b7737faf3048974f1e1fdab518