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Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations
- Source :
- Clinical and Experimental Immunology. 135:490-496
- Publication Year :
- 2004
- Publisher :
- Oxford University Press (OUP), 2004.
-
Abstract
- SUMMARY Anti-Saccharomyces cerevisiae antibodies (ASCAs) have been proposed as serological markers, which may differentiate Crohn's disease (CD) from ulcerative colitis (UC) and predict disease phenotype. Their importance in pathogenesis is unproven. We investigated the relationship between ASCAs, disease phenotype and NOD2/CARD15 genotype in CD and whether ASCAs were related to antibodies to other fungal proteins. Serum from 228 patients [143 CD, 75 UC, 10 with indeterminate colitis (IC)] and 78 healthy controls (HC) were assayed for ASCA. Antibodies (IgA, IgG) to other fungal proteins (Fusarium species ATC20334, Mycoprotein) were measured in the same samples using an in-house enzyme-linked immunosorbent assay (ELISA) assay. ASCAs were present in 57% of CD, 19% of UC, 30% of IC and 8% of HCs. ASCA-positive status was a predictor for CD with sensitivity of 57%, specificity of 87%, positive predictive value of 78% and negative predictive value of 68%. ASCA was associated with proximal (gastroduodenal and small bowel involvement) rather than purely colonic disease (P
- Subjects :
- Adult
Male
Adolescent
Genotype
Immunology
Nod2 Signaling Adaptor Protein
Saccharomyces cerevisiae
Biology
Sensitivity and Specificity
Immunoglobulin G
Serology
Pathogenesis
Crohn Disease
Immunopathology
NOD2
Clinical Studies
medicine
Humans
Immunology and Allergy
Age of Onset
Antibodies, Fungal
Aged
Aged, 80 and over
Fungal protein
Crohn's disease
Intracellular Signaling Peptides and Proteins
Middle Aged
medicine.disease
Ulcerative colitis
digestive system diseases
Immunoglobulin A
Phenotype
Mutation
Disease Progression
biology.protein
Colitis, Ulcerative
Female
Carrier Proteins
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 13652249 and 00099104
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....2886954a6d64220b014b00e3425bdb41