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Sex dependent effects of physical activity on diet preference in rats selectively bred for high or low levels of voluntary wheel running
- Source :
- Behavioural Brain Research. 359:95-103
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Considering the current obesity epidemic is due in large part to an energy imbalance, it is crucial to explore biological mechanisms that mediate palatable high energy food intake and physical activity behavior levels. Previous research demonstrates a unique sex dependent influence of physical activity on diet preference, specifically changes in palatable high-fat diet intake. Therefore, factors of motivation may be underlying the differential effect of physical activity in male and female rats on their diet preference. The present study extends this hypothesis by assessing diet preference in male and female Wistar rats selectively bred for high (HVR) and low (LVR) levels of voluntary wheel running distances. HVR and LVR rats were housed under either sedentary (SED) or voluntary wheel running access (RUN) conditions for the duration of the study. Following a 1 week acclimation period to these conditions, standard chow was replaced with concurrent ad libitum access to a choice of 3 pelleted diets (high-fat, high-sucrose, and high-corn starch); all 3 were provided in the home cage. Body weight, running distance, and intake of each diet was measured daily. At the conclusion of the 4 week diet preference test, animals were sacrificed and ventral striatum tissue was collected for later analysis. Results demonstrated intake patterns of diets were uniquely influenced by physical activity dependent on both the sex and the selectively bred line of rat. In addition, reward related ventral striatal mRNA expression was also dependent on both the sex and the selectively bred line of rat. Overall, the pattern of both behavioral and mRNA results suggest that voluntary wheel running behavior differentially mediates palatable diet consumption in males and females. Considering the pervasive abundance of both physical inactivity, combined with over-consumption of energy dense palatable diets, it is vital to understand the nature of these behavioral interactions.
- Subjects :
- Male
Volition
medicine.medical_specialty
Period (gene)
Motor Activity
Biology
Nucleus accumbens
Diet, High-Fat
Selective breeding
Running
Eating
Food Preferences
03 medical and health sciences
Behavioral Neuroscience
Sex Factors
0302 clinical medicine
Reward
Species Specificity
Dietary Sucrose
Preference test
Internal medicine
medicine
Animals
RNA, Messenger
Rats, Wistar
030304 developmental biology
computer.programming_language
0303 health sciences
sed
Body Weight
Ventral striatum
Starch
medicine.disease
Obesity
Endocrinology
medicine.anatomical_structure
Turnover
Ventral Striatum
Female
Sedentary Behavior
computer
030217 neurology & neurosurgery
Selective Breeding
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 359
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....2882ce49ff5228441ba5c0c9fa8beb51