Quantification anomalies in single pulse LA-ICP-MS analysis associated with laser fluence and beam size

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has undergone major improvements in recent years which have led to reduction of the analysis time, higher spatial resolution, and better sensitivity. However, quantification and accurate analysis remain one of the bottlenecks in LA-ICP-MS analysis and so far satisfactory calibration solutions are restricted to well-documented matrices and suitable internal standards. Additional uncertainties associated with laser fluence and beam size