Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs?

Objective The aim of this study was to compare the differential response to amisulpride in patients with paranoid versus disorganized schizophrenia. Method We reanalyzed the original data from five different randomized drug trials comparing Brief Psychiatric Rating Scale (BPRS) scores in a database containing 427 paranoid and 296 disorganized patients with schizophrenia. Results Both the disorganized and the paranoid group showed a substantial improvement of the BPRS total score within the first 4 weeks. In the paranoid group, mean (±SD) BPRS reduction was 16.9 (±14.6) (t = 24.06, df = 426, P