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The Effects of Pulsatilla Koreana NAKAI Pharmacopuncture Therapy on the Chunchu (ST25) for Dextran Sulfate Sodium-Induced Colitis in Mice
- Source :
- Journal of Acupuncture Research, Vol 35, Iss 1, Pp 11-20 (2018)
- Publication Year :
- 2018
- Publisher :
- Korean Acupuncture and Moxibustion Medicine Society, 2018.
-
Abstract
- Background This research was performed to investigate the effects of Pulsatilla Koreana NAKAI pharmacopuncture (PPA) therapy on intestinal disease in rats with dextran sulfate sodium (DSS)-induced colitis. Methods The subjects were divided into five groups : A control group, saline group, pharmacopuncture group PPA1 (0.2 ㎎/ 1 kg/ 40 ㎕), pharmacopuncture group PPA2 (0.5 ㎎/ 1 kg/ 40 ㎕), and pharmacopuncture group PPA 3(1 ㎎/ 1 kg/ 40 ㎕). The experimental model of colitis was induced by infection of dextran sulfate sodium (DSS) for eighteen days. After colitis was induced, PPA therapy was practiced on the Chunchu (ST25) once every two days for a total six times. Thereafter Disease Activity Index (DAI), colon length, damage to the colonic mucosa, body weight, IL-6, IL-10, IL-1β, IFN-γ, TNF-α, TGF-β1, IL-23 and IL-17 were measured. Results The results were as follows. 1. DAI was significantly decreased in the PPA groups. 2. Colon length was significantly increased in the PPA groups. 3. Damage of colonic mucosa was observed less in the PPA groups. 4. Body weight was significantly increased in the saline group and the PPA groups. 5. The PPA2 group showed a significant decrease in the intensity of IL-6, IL-1β, IFN-γand TNF-α levels and the mean of IL-23. 6. The PPA3 group showed a significant increase in the intensity of IL-10 and TGF-β1 levels. 7. No significant differences were shown in the mean of IL-17. Conclusions These results suggest that PPA therapy on Chunchu (ST25) can be used as an effective treatment for inflammatory bowel disease.
- Subjects :
- colitis
medicine.medical_treatment
pharmacopuncture
Pharmacology
030226 pharmacology & pharmacy
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
cytokine
medicine
Chunchu (ST25)
Colitis
Dextran Sulfate Sodium
lcsh:Miscellaneous systems and treatments
biology
business.industry
lcsh:RM1-950
respiratory system
lcsh:RZ409.7-999
biology.organism_classification
medicine.disease
030205 complementary & alternative medicine
lcsh:Therapeutics. Pharmacology
Cytokine
Dextran
chemistry
dextran sulfate sodium
Pulsatilla Koreana NAKAI
business
Pulsatilla koreana
Subjects
Details
- ISSN :
- 25862898 and 2586288X
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Journal of Acupuncture Research
- Accession number :
- edsair.doi.dedup.....2868685844b3c95d02c5e4fb83518a4d
- Full Text :
- https://doi.org/10.13045/jar.2018.00024