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Macromolecular Platform with Super-Cation Enhanced Trans-Cornea Infiltration for Noninvasive Nitric Oxide Delivery in Ocular Therapy
- Source :
- ACS Nano. 14:16929-16938
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- The cornea provides important protection for human eyes from invasion of alien substances. However, its blockage on the infiltration of molecules also constitutes a great challenge for noninvasive trans-cornea delivery of drugs. Here we report polyamino acid-based S-nitrosothiols with high cationic charge density as a NO carrier to overcome cornea associated blockage in ophthalmological therapy. Our results demonstrate that the cationic nature of the polymer promoted transcytosis, which greatly enhances the trans-cornea delivery of the NO donor and bypasses cornea barriers on passive drug diffusion. The combination of super cation and glutathione responsiveness synergistically enhanced intraocular delivery of topically administered poly(2-acetamido-N-triethylenetetramine-3-nitrosothiol-3-methylbutanamide)aspartamide, effectively alleviating high intraocular pressure in mice with glaucoma. Such a noninvasive "barrier hopping" approach not only serves as an inspiration in improving the efficiency of trans-cornea drug delivery but also has great potential in overcoming drug transporting barriers in other biomedical applications.
- Subjects :
- Drug
Polyamino acid
media_common.quotation_subject
General Physics and Astronomy
02 engineering and technology
010402 general chemistry
01 natural sciences
Nitric oxide
No donors
chemistry.chemical_compound
Cornea
medicine
General Materials Science
media_common
Chemistry
General Engineering
021001 nanoscience & nanotechnology
medicine.disease
eye diseases
0104 chemical sciences
medicine.anatomical_structure
Transcytosis
Drug delivery
Biophysics
sense organs
0210 nano-technology
Infiltration (medical)
Subjects
Details
- ISSN :
- 1936086X and 19360851
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- ACS Nano
- Accession number :
- edsair.doi.dedup.....2864f719f0422248d749acf7fb202188