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A new method to investigate brain stem structural-functional correlations using digital post-processing MRI - reliability in ischemic internuclear ophthalmoplegia
- Source :
- European Journal of Neurology. 8:489-493
- Publication Year :
- 2001
- Publisher :
- Wiley, 2001.
-
Abstract
- We investigated the reliability of a new digital post-processing magnetic resonance imaging (MRI) technique in ischemic brain stem lesions to identify relations of the lesion to anatomical brain stem structures. The target was a medial longitudinal fasciculus (MLF) lesion, which was evident from ipsilateral internuclear ophthalmoplegia (INO). Sixteen patients with acute unilateral INO and an isolated acute brain stem lesion in T2- and EPI-diffusion weighted MRI within 2 days after the onset of symptoms were studied. The MRI slice direction was parallel and perpendicular to a slice selection of a stereotactic anatomical atlas. The individual slices were normalized and projected in the digitalized atlas. The eye movement disorder was monitored by electro-oculography. In all patients with clinical or subclinical electro-oculographically documented INO and MRI proven brain stem infarction the lesion covered or at least partially overlapped the ipsilateral MLF at one or more atlas levels. We conclude that digital post-processing MRI with normalizing and projecting brain stem lesions in an anatomical atlas is a reliable method to demonstrate the anatomical structures involved by the lesion. Combined with electrophysiological brain stem testing, this method may be a useful tool to identify incompletely understood pathways mediating brain stem reflexes or the generators of evoked potentials.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Internuclear ophthalmoplegia
Anatomical structures
Lesion
Image Processing, Computer-Assisted
medicine
Humans
Aged
Brain Mapping
Ophthalmoplegia
medicine.diagnostic_test
business.industry
Reproducibility of Results
Eye movement
Magnetic resonance imaging
Anatomy
Middle Aged
Medial longitudinal fasciculus
medicine.disease
Magnetic Resonance Imaging
Electrooculography
Electrophysiology
Neurology
Slice selection
Female
Neurology (clinical)
medicine.symptom
business
Brain Stem
Subjects
Details
- ISSN :
- 14681331 and 13515101
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- European Journal of Neurology
- Accession number :
- edsair.doi.dedup.....285edb7f83df17869ce2bd9f0e2ce90c