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ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration
- Source :
- Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Cellular Physiology and Biochemistry, Vol 44, Iss 3, Pp 1120-1132 (2017)
- Publication Year :
- 2017
- Publisher :
- S. Karger AG, 2017.
-
Abstract
- Epithelial sodium channels (ENaC) play an important role in re-absorbing excessive luminal fluid by building up an osmotic Na+ gradient across the tight epithelium in the airway, the lung, the kidney, and the colon. The ENaC is a major pathway for retention of salt in kidney too. MicroRNAs (miRs), a group of non-coding RNAs that regulate gene expression at the post-transcriptional level, have emerged as a novel class of regulators for ENaC. Given the ENaC pathway is crucial for maintaining fluid homeostasis in the lung and the kidney and other cavities, we summarized the cross-talk between ENaC and miRs and recapitulated the underlying regulatory factors, including aldosterone, transforming growth factor-β1, and vascular endothelial growth factor-A in the lung and other epithelial tissues/organs. We have compared the profiling of miRs between normal and injured mice and human lungs, which showed a significant alteration in numerous miRs in mouse models of LPS and ventilator induced ARDS. In addition, we reiterated the potential regulation of the ENaC by miRs in stem/ progenitor cell-based re-epithelialization, and identified a promising pharmaceutic target of ENaC for removing edema fluid in ARDS by mesenchymal stem cells-released paracrine. In conclusion, it seems that the interactions between miRs and scnn1s/ENaCs are critical for lung development, epithelial cell turnover in adult lungs, and re-epithelialization for repair.
- Subjects :
- 0301 basic medicine
Epithelial sodium channel
Physiology
Cross talk
Biology
lcsh:Physiology
Epithelium
Article
lcsh:Biochemistry
03 medical and health sciences
Paracrine signalling
microRNA
medicine
Animals
Humans
Regeneration
lcsh:QD415-436
Epithelial reparation
Amiloride-sensitive sodium channels
Progenitor cell
Epithelial Sodium Channels
Stem/progenitor cells
Non-coding RNA
Lung
Transepithelial sodium transport
Kidney
lcsh:QP1-981
urogenital system
Stem Cells
Mesenchymal stem cell
respiratory system
3. Good health
Cell biology
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
Stem cell
hormones, hormone substitutes, and hormone antagonists
Re-epithelialization
Subjects
Details
- ISSN :
- 14219778 and 10158987
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Cellular Physiology and Biochemistry
- Accession number :
- edsair.doi.dedup.....2859e3f9e413cf1125ca8ef4b3bd7616