Metagenomic analysis reveals presence of different animal viruses in commercial fetal bovine serum and trypsin

Animal-derived biological products, such as fetal bovine serum (FBS) and trypsin, are important supplements for scientific, pharmaceutical, and medical use. Although preventive guidelines and tests are implemented to reduce potential viral contamination in these biologicals, they do not target unusual or emerging viruses, leading to safety concerns. Using unbiased metagenomics, we investigated the presence of viruses in recently collected commercial FBS and trypsin samples from different geographic regions. In total, we detected viral sequences belonging to动物源性的生物制品，如胎牛血清（FBS）和胰蛋白酶（Trypsin），是科学、制药和医疗等领域的重要添加成分。尽管采取了预防性的指南和措施来减少这些生物制品中潜在的病毒污染，但是这些措施并未针对罕见的或新发的病毒，因此可能会导致潜在的安全问题。我们使用无偏的宏基因组方法，对来自不同区域的商业FBS和Trypsin样本中携带的病毒进行了分析。我们检测到了