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Polymorphism of vascular endothelial growth factor -2578C/A with cancer risk: evidence from 11263 subjects
- Source :
- Medical oncology (Northwood, London, England). 28(4)
- Publication Year :
- 2010
-
Abstract
- Published data on the association between vascular endothelial growth factor (VEGF) –2578C/A polymorphism and cancer risk is inconclusive. To derive a more precise estimation of association between VEGF –2578C/A polymorphism and the risk of cancer, we performed a meta-analysis of 5415 cancer cases and 5848 controls from 16 published case–control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Our meta-analysis indicated that VEGF –2578C/A polymorphism was associated with the risk of colorectal cancer under homozygote comparison (OR = 0.70, 95% CI = 0.53–0.92), dominant model (OR = 0.72, 95% CI = 0.57–0.92), and recessive model (OR = 0.82, 95% CI = 0.67–1.01), although no evidence of association between VEGF –2578C/A polymorphism and cancer risk was observed as we compared in the pooled analyses (homozygote comparison: OR = 0.97, 95% CI = 0.81–1.16). More studies are needed to detect VEGF –2578C/A polymorphism and its association with cancer in different ethnic populations incorporated with environmental exposures in the susceptibility of different kinds of cancer.
- Subjects :
- Oncology
Male
Vascular Endothelial Growth Factor A
Cancer Research
medicine.medical_specialty
Colorectal cancer
Polymorphism, Single Nucleotide
chemistry.chemical_compound
Risk Factors
Internal medicine
Neoplasms
Medicine
Humans
Genetic Predisposition to Disease
Genetics
Hematology
business.industry
Case-control study
General Medicine
Odds ratio
medicine.disease
Confidence interval
Vascular endothelial growth factor
chemistry
Meta-analysis
Case-Control Studies
Female
business
Cancer risk
Subjects
Details
- ISSN :
- 1559131X
- Volume :
- 28
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Medical oncology (Northwood, London, England)
- Accession number :
- edsair.doi.dedup.....28540d2f069ebcacd6d0368420438a03