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Spatial regulation of the actin cytoskeleton by HSF-1 during aging
- Source :
- Molecular Biology of the Cell
- Publication Year :
- 2018
-
Abstract
- There are many studies suggesting an age-associated decline in the actin cytoskeleton, and this has been adopted as common knowledge in the field of aging biology. However, a direct identification of this phenomenon in aging multicellular organisms has not been performed. Here, we express LifeAct::mRuby in a tissue-specific manner to interrogate cytoskeletal organization as a function of age. We show for the first time in Caenorhabditis elegans that the organization and morphology of the actin cytoskeleton deteriorate at advanced age in the muscles, intestine, and hypodermis. Moreover, hsf-1 is essential for regulating cytoskeletal integrity during aging, so that knockdown of hsf-1 results in premature aging of actin and its overexpression protects actin cytoskeletal integrity in the muscles, the intestine, and the hypodermis. Finally, hsf-1 overexpression in neurons alone is sufficient to protect cytoskeletal integrity in nonneuronal cells.
- Subjects :
- 0301 basic medicine
Aging
Longevity
03 medical and health sciences
Animals
Homeostasis
Cytoskeleton
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Molecular Biology
Actin
Neurons
biology
Extramural
Brief Report
Cell Biology
biology.organism_classification
Actin cytoskeleton
Actins
Cell biology
Actin Cytoskeleton
030104 developmental biology
Organ Specificity
Transcription Factors
Subjects
Details
- ISSN :
- 19394586
- Volume :
- 29
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Molecular biology of the cell
- Accession number :
- edsair.doi.dedup.....2853b29aabd7a3b5c7cae60e9c60cade