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Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study
- Source :
- BMJ Open
- Publication Year :
- 2018
-
Abstract
- ObjectivesTo investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population.DesignProspective cohort study.SettingGuangzhou Government Servant Physical Check-up Center, Guangzhou, China.Participants4413 government employees aged no less than 40 years (41.9% female) attending annual physical and eye examinations were included in this study. The inclusion criterion was having attended the 2010 follow-up examination. The exclusion criteria include glaucoma or intraocular surgery history, IOP >21 mm Hg at any visit or without available IOP data at all visits from 2010 to 2014.Primary and secondary outcome measuresThe outcome measure was IOP at each follow-up visit from 2010 to 2014. Mixed-effect model was used to assess the relationship between longitudinal changes in IOP and potential risk factors.ResultsFor the 2653 participants who had available IOP data at both the 2010 and 2014 follow-up visits, the average change in IOP was an increase of 0.43 (95% CI 0.36 to 0.50) mm Hg. For the whole study population and in the optimised mixed model, there was a non-linear increase of IOP with age (PConclusionsIn this cohort of elderly Chinese adults, IOP increases non-linearly with ageing. People with increasing blood pressure, BMI, FPG and myopic progression are more likely to have IOP elevation over time.
- Subjects :
- 0301 basic medicine
Blood Glucose
Male
Intraocular pressure
Refractive error
Aging
genetic structures
Cross-sectional study
Glaucoma
Blood Pressure
Body Mass Index
0302 clinical medicine
Risk Factors
Myopia
Prospective Studies
refractive error
Prospective cohort study
education.field_of_study
Age Factors
General Medicine
Middle Aged
Refractive Errors
Cohort
Hypertension
Female
Cohort study
medicine.medical_specialty
China
longitudinal
Population
03 medical and health sciences
Tonometry, Ocular
Sex Factors
Ophthalmology
medicine
Humans
education
Intraocular Pressure
Aged
business.industry
Research
medicine.disease
eye diseases
030104 developmental biology
Cross-Sectional Studies
Hyperglycemia
030221 ophthalmology & optometry
sense organs
business
Subjects
Details
- ISSN :
- 20446055
- Volume :
- 8
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- BMJ open
- Accession number :
- edsair.doi.dedup.....2845019362b997ed572358e0a2dedcb5