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MicroRNA-320a inhibits cell proliferation, migration and invasion by targeting BMI-1 in nasopharyngeal carcinoma
- Source :
- FEBS letters. 588(20)
- Publication Year :
- 2014
-
Abstract
- In the present study, we investigated the roles and molecular mechanisms of miR-320a in human nasopharyngeal carcinoma (NPC). miR-320a expression was strongly reduced in NPC tissues and cell lines. Overexpression of miR-320a significantly suppressed NPC cell growth, migration, invasion and tumor growth in a xenograft mouse model. A luciferase reporter assay revealed that miR-320a could directly bind to the 3′ UTR of BMI-1. Overexpression of BMI-1 rescued miR-320a-mediated biological function. BMI-1 expression was found to be up-regulated and inversely correlated with miR-320a expression in NPC. Collectively, our data indicate that miR-320a plays a tumor suppressor role in the development and progression of NPC and may be a novel therapeutic target against NPC.
- Subjects :
- Untranslated region
Proliferation
Biophysics
Mice, Nude
Biology
Biochemistry
law.invention
Mice
Invasion
Structural Biology
law
Cell Movement
Cell Line, Tumor
microRNA
Nasopharyngeal carcinoma
otorhinolaryngologic diseases
Genetics
medicine
Animals
Humans
Tumor growth
Neoplasm Invasiveness
Molecular Biology
3' Untranslated Regions
Cell Proliferation
Polycomb Repressive Complex 1
Mice, Inbred BALB C
Luciferase reporter
Cell growth
Carcinoma
Nasopharyngeal Neoplasms
Cell Biology
Neoplasms, Experimental
medicine.disease
BMI-1
miR-320a
Up-Regulation
Gene Expression Regulation, Neoplastic
stomatognathic diseases
MicroRNAs
Cell culture
Immunology
Cancer research
Suppressor
Subjects
Details
- ISSN :
- 18733468
- Volume :
- 588
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....2840529c77df08fd8401ca78267b299b