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MicroRNA-320a inhibits cell proliferation, migration and invasion by targeting BMI-1 in nasopharyngeal carcinoma

Authors :
Xiaoming Qi
Changbo Zhou
Chunlei Lv
Min Tian
Jianqiang Li
Source :
FEBS letters. 588(20)
Publication Year :
2014

Abstract

In the present study, we investigated the roles and molecular mechanisms of miR-320a in human nasopharyngeal carcinoma (NPC). miR-320a expression was strongly reduced in NPC tissues and cell lines. Overexpression of miR-320a significantly suppressed NPC cell growth, migration, invasion and tumor growth in a xenograft mouse model. A luciferase reporter assay revealed that miR-320a could directly bind to the 3′ UTR of BMI-1. Overexpression of BMI-1 rescued miR-320a-mediated biological function. BMI-1 expression was found to be up-regulated and inversely correlated with miR-320a expression in NPC. Collectively, our data indicate that miR-320a plays a tumor suppressor role in the development and progression of NPC and may be a novel therapeutic target against NPC.

Details

ISSN :
18733468
Volume :
588
Issue :
20
Database :
OpenAIRE
Journal :
FEBS letters
Accession number :
edsair.doi.dedup.....2840529c77df08fd8401ca78267b299b