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Protective Effects of Apoptosis of Kupffer Cells Induced by Zoledronate Liposomes Following Hepatic Ischemia-Reperfusion Injury
- Source :
- Annals of Transplantation
- Publication Year :
- 2018
- Publisher :
- International Scientific Information, Inc., 2018.
-
Abstract
- BACKGROUND The goal of this study was to observe the effect of the apoptosis of Kupffer cells (KCs) selectively induced by zoledronate liposomes following the hepatic ischemia-reperfusion injury (IRI) in the rat liver transplantation model and to explore its mechanisms. MATERIAL AND METHODS The rat liver transplantation model was established using the improved Kamada method. Male Sprague Dawley rats were randomly divided into 3 groups: no liver transplantation or drug treatment (Group A); donor rats were injected with 1 mL normal saline through the tail vein for 3 continuous days before transplantation, and the donor liver was preserved in cold for 2 hours (Group B); donor rats were injected with 1 mL zoledronate liposomes (0.001 mg/mL) through the tail vein for 3 continuous days before transplantation, and the donor liver was preserved in cold for 2 hours (Group C). At 24 hours after transplantation, the receiving rats were sacrificed for sampling. RESULTS Compared with Group C and Group A, the bile secretion flow was dramatically decreased in Group B, whereas the serum liver function index [alanine aminotransferase (ALT), glutamate aminotransferase (AST), and γ-glutamyl transpeptidase (γ-GT)] was significantly increased (P
- Subjects :
- Male
medicine.medical_specialty
Necrosis
Kupffer Cells
medicine.medical_treatment
Apoptosis
Liver transplantation
Protective Agents
Zoledronic Acid
Rats, Sprague-Dawley
Random Allocation
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Saline
Original Paper
Transplantation
business.industry
General Medicine
medicine.disease
Liver Transplantation
Rats
Endocrinology
Reperfusion Injury
030220 oncology & carcinogenesis
Liposomes
030211 gastroenterology & hepatology
Tumor necrosis factor alpha
Liver function
medicine.symptom
business
Reperfusion injury
Biomarkers
Subjects
Details
- ISSN :
- 23290358
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Annals of Transplantation
- Accession number :
- edsair.doi.dedup.....283589a80c469ab9114e1d6ec09d2ca8