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Transcriptomic profiles in peripheral blood between women with unexplained recurrent implantation failure and recurrent miscarriage and the correlation with endometrium: A pilot study
- Source :
- PLoS ONE, Vol 12, Iss 12, p e0189159 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Aim To study the transcriptome profiles in the blood of recurrent implantation failure (RIF), recurrent miscarriage (RM) and fertile women during the window of implantation, and further analysis the correlation of transcriptome profiles between blood and endometrium. Methods This is an observational prospective study. In total 9 subjects were recruited, 3 RIF, 3 RM, and 3 controls. Paired samples (endometrium and peripheral blood) from the same subjects were precisely timed on the 7th days after luteal hormone surge (LH+7). RNA sequencing was applied to investigate the transcriptome profiles. Results The results of transcriptome in peripheral blood cannot be used to characterize women with RIF and unexplained RM. There was a medium level correlation between transcriptome in peripheral blood and endometrium during the window of implantation. Conclusion The differential transcriptome patterns in blood are not representative of those in endometrium, and the blood transcriptome cannot differentiate among the women with RIF, RM or fertile.
- Subjects :
- 0301 basic medicine
Physiology
Molecular biology
Maternal Health
Biopsy
Gene Expression
lcsh:Medicine
Pilot Projects
Miscarriage
Endometrium
Transcriptome
Correlation
Sequencing techniques
Mathematical and Statistical Techniques
0302 clinical medicine
Pregnancy
Recurrent miscarriage
Medicine and Health Sciences
Prospective cohort study
lcsh:Science
Principal Component Analysis
030219 obstetrics & reproductive medicine
Multidisciplinary
medicine.diagnostic_test
Obstetrics and Gynecology
RNA sequencing
Genomics
Body Fluids
Blood
medicine.anatomical_structure
Physical Sciences
Female
Anatomy
Transcriptome Analysis
Statistics (Mathematics)
Research Article
Abortion, Habitual
Surgical and Invasive Medical Procedures
Andrology
03 medical and health sciences
Genetics
medicine
Humans
Embryo Implantation
Statistical Methods
business.industry
Uterus
lcsh:R
Reproductive System
Biology and Life Sciences
Computational Biology
Genome Analysis
medicine.disease
Peripheral blood
Pregnancy Complications
Research and analysis methods
Molecular biology techniques
030104 developmental biology
Multivariate Analysis
Women's Health
lcsh:Q
business
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....28245122cfabb30ca0b6899407e2ad79