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(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor
- Source :
- Journal of Medicinal Chemistry. 41:1357-1360
- Publication Year :
- 1998
- Publisher :
- American Chemical Society (ACS), 1998.
- Subjects :
- Male
Anti-HIV Agents
Pyridines
Stereochemistry
Human immunodeficiency virus (HIV)
Thio
medicine.disease_cause
Chemical synthesis
Cell Line
Nucleoside Reverse Transcriptase Inhibitor
Rats, Sprague-Dawley
Broad spectrum
Drug Discovery
medicine
Animals
Delavirdine
Bicyclic molecule
Chemistry
Drug Resistance, Microbial
Stereoisomerism
Biological activity
HIV Reverse Transcriptase
Rats
Pyrimidines
Mutation
HIV-1
Reverse Transcriptase Inhibitors
Molecular Medicine
medicine.drug
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....2821bb7f749a376a1a2d6c7a50b95408