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Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation: Results from the EXIST study
- Source :
- PLoS ONE, 12(7). Public Library of Science, Persoon, S, ChinAPaw, M J M, Buffart, L M, Liu, R D K, Wijermans, P, Koene, H R, Minnema, M C, Lugtenburg, P J, Marijt, E W A, Brug, J, Nollet, F & Kersten, M J 2017, ' Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation : Results from the EXIST study ', PLoS ONE, vol. 12, no. 7, e0181313 . https://doi.org/10.1371/journal.pone.0181313, PLoS ONE, PLoS ONE [E], 12(7). Public Library of Science, PLoS ONE, Vol 12, Iss 7, p e0181313 (2017), PLoS ONE, 12(7):e0181313. Public Library of Science, PLoS One (print), 12(7):e0181313. Public Library of Science, PLoS ONE, 12(7)
- Publication Year :
- 2017
-
Abstract
- Background: This single blind, multicenter randomized controlled trial aimed to evaluate the effectiveness of a supervised high intensity exercise program on physical fitness and fatigue in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation. Methods: 109 patients were randomly assigned to the 18-week exercise intervention or the usual care control group. The primary outcomes included physical fitness (VO2peak and Wpeak determined using a cardiopulmonary exercise test; grip strength and the 30s chair stand test) and fatigue (Multidimensional Fatigue Inventory) and were assessed prior to randomization and after completion of the intervention or at similar time points for the control group. Multivariable multilevel linear regression analyses were performed to assess intervention effects. Results: Patients in the intervention group attended 86% of the prescribed exercise sessions. Of the patients in the control group, 47% reported ≥10 physiotherapy sessions, which most likely included supervised exercise, suggesting a high rate of contamination. Median improvements in physical fitness ranged between 16 and 25% in the intervention group and between 12 and 19% in the control group. Fatigue decreased in both groups. There were no significant differences between the intervention and control group. Conclusion: We found no significant beneficial effects of the supervised high intensity exercise program on physical fitness and fatigue when compared to usual care. We hypothesized that the lack of significant intervention effects may relate to suboptimal timing of intervention delivery, contamination in the control group and/or suboptimal compliance to the prescribed exercise intervention. Trial registration: Netherlands Trial Register—NTR2341.
- Subjects :
- Male
Lymphoma
Physical fitness
Cancer Treatment
lcsh:Medicine
High-Intensity Interval Training
Pathology and Laboratory Medicine
Biochemistry
law.invention
Grip strength
0302 clinical medicine
Autologous stem-cell transplantation
Randomized controlled trial
law
Medicine and Health Sciences
Medicine
Single-Blind Method
Public and Occupational Health
030212 general & internal medicine
lcsh:Science
Physiotherapy
Fatigue
Multidisciplinary
Agricultural and Biological Sciences(all)
Middle Aged
Sports Science
Exercise Therapy
Oncology
030220 oncology & carcinogenesis
Strength Training
Female
Multiple Myeloma
High-intensity interval training
Research Article
Adult
medicine.medical_specialty
Randomization
Drug-Related Side Effects and Adverse Reactions
Strength training
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Intervention (counseling)
Humans
Sports and Exercise Medicine
Exercise
Aged
business.industry
Biochemistry, Genetics and Molecular Biology(all)
lcsh:R
Biology and Life Sciences
Physical Activity
Health Care
Physical Fitness
Physical therapy
lcsh:Q
business
Genetics and Molecular Biology(all)
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, 12(7). Public Library of Science, Persoon, S, ChinAPaw, M J M, Buffart, L M, Liu, R D K, Wijermans, P, Koene, H R, Minnema, M C, Lugtenburg, P J, Marijt, E W A, Brug, J, Nollet, F & Kersten, M J 2017, ' Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation : Results from the EXIST study ', PLoS ONE, vol. 12, no. 7, e0181313 . https://doi.org/10.1371/journal.pone.0181313, PLoS ONE, PLoS ONE [E], 12(7). Public Library of Science, PLoS ONE, Vol 12, Iss 7, p e0181313 (2017), PLoS ONE, 12(7):e0181313. Public Library of Science, PLoS One (print), 12(7):e0181313. Public Library of Science, PLoS ONE, 12(7)
- Accession number :
- edsair.doi.dedup.....280d66ddd3e19f408711e5d266ef121e