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Common Lung Microbiome Identified among Mechanically Ventilated Surgical Patients

Authors :
Ryan M. Huebinger
Ashley D. Smith
Michael S. Allen
Christian T. Minshall
Robert Barber
Yan Zhang
Source :
PLoS ONE, PLoS ONE, Vol 11, Iss 11, p e0166313 (2016)
Publication Year :
2016
Publisher :
Public Library of Science, 2016.

Abstract

The examination of the pulmonary microbiome in patients with non-chronic disease states has not been extensively examined. Traditional culture based screening methods are often unable to identify bacteria from bronchoalveolar lavage samples. The advancement of next-generation sequencing technologies allows for a culture-independent molecular based analysis to determine the microbial composition in the lung of this patient population. For this study, the Ion Torrent PGM system was used to assess the microbial complexity of culture negative bronchoalveolar lavage samples. A group of samples were identified that all displayed high diversity and similar relative abundance of bacteria. This group consisted of Hydrogenophaga, unclassified Bacteroidetes, Pedobacter, Thauera, and Acinetobacter. These bacteria may be representative of a common non-pathogenic pulmonary microbiome associated within this population of patients.

Details

Language :
English
ISSN :
19326203
Volume :
11
Issue :
11
Database :
OpenAIRE
Journal :
PLoS ONE
Accession number :
edsair.doi.dedup.....2805412727c00325ebd36c00d69b66ca