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Level of agreement between frequently used cardiovascular risk calculators in people living with HIV
- Source :
- HIV medicine. 20(5)
- Publication Year :
- 2019
-
Abstract
- Objectives\ud\udThe aim of the study was to describe agreement between the QRISK2, Framingham and Data Collection on Adverse Events of Anti‐HIV Drugs (D:A:D) cardiovascular disease (CVD) risk calculators in a large UK study of people living with HIV (PLWH).\ud\ud\udMethods\ud\udPLWH enrolled in the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study without a prior CVD event were included in this study. QRISK2, Framingham CVD and the full and reduced D:A:D CVD scores were calculated; participants were stratified into ‘low’ (< 10%), ‘intermediate’ (10–20%) and ‘high’ (> 20%) categories for each. Agreement between scores was assessed using weighted kappas and Bland–Altman plots.\ud\udResults\ud\udThe 730 included participants were predominantly male (636; 87.1%) and of white ethnicity (645; 88.5%), with a median age of 53 [interquartile range (IQR) 49–59] years. The median calculated 10‐year CVD risk was 11.9% (IQR 6.8–18.4%), 8.9% (IQR 4.6–15.0%), 8.5% (IQR 4.8–14.6%) and 6.9% (IQR 4.1–11.1%) when using the Framingham, QRISK2, and full and reduced D:A:D scores, respectively. Agreement between the different scores was generally moderate, with the highest level of agreement being between the Framingham and QRISK2 scores (weighted kappa = 0.65) but with most other kappa coefficients in the 0.50–0.60 range.\ud\ud\udConclusions\ud\udEstimates of predicted 10‐year CVD risk obtained with commonly used CVD risk prediction tools demonstrate, in general, only moderate agreement among PLWH in the UK. While further validation with clinical endpoints is required, our findings suggest that care should be taken when interpreting any score alone.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Cvd risk
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Risk Assessment
Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) risk score
Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study
03 medical and health sciences
0302 clinical medicine
Interquartile range
Virology
Internal medicine
medicine
Clinical endpoint
Humans
Pharmacology (medical)
030212 general & internal medicine
Prospective Studies
Adverse effect
Framingham
Framingham Risk Score
business.industry
Health Policy
HIV
1103 Clinical Sciences
Middle Aged
030112 virology
QRISK2
United Kingdom
Infectious Diseases
Cardiovascular Diseases
cardiovascular risk prediction
Female
business
agreement
Kappa
Algorithms
Subjects
Details
- ISSN :
- 14681293 and 14642662
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- HIV medicine
- Accession number :
- edsair.doi.dedup.....27fa7adc3ecc09b4bf65407bb9bd9872