Back to Search
Start Over
A Carbonylation Approach Toward Activation of Csp2-H and Csp3-H Bonds: Cu-Catalyzed Regioselective Cross Coupling of Imidazo[1,2-a]pyridines with Methyl Hetarenes
- Source :
- Organic letters. 18(15)
- Publication Year :
- 2016
-
Abstract
- An efficient copper-catalyzed selective cross coupling of imidazo[1,2-a]pyridines with methyl hetarenes has been reported. This transformation opened a new route to synthesize the C-3 carbonyl imidazo[1,2-a]pyridine derivative, which is a common structural motif in natural products and pharmaceuticals. (18)O-labeling experiments indicated that the oxygen source of products originated from O2.
- Subjects :
- 010405 organic chemistry
Stereochemistry
Organic Chemistry
Regioselectivity
chemistry.chemical_element
010402 general chemistry
01 natural sciences
Biochemistry
Medicinal chemistry
Oxygen
0104 chemical sciences
Catalysis
Coupling (electronics)
chemistry.chemical_compound
chemistry
Pyridine
Physical and Theoretical Chemistry
Structural motif
Carbonylation
Derivative (chemistry)
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 18
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....27fa177bd21431cb4b3a8842b41cdf91