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Humanized Mice Reproduce Acute and Persistent Human Adenovirus Infection
- Source :
- Journal of Infectious Diseases. 215:70-79
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Severe human adenovirus (HAdV) infections are an increasing threat for immunosuppressed individuals, particularly those who have received stem cell transplants. It has been previously hypothesized that severe infections might be due to reactivation of a persistent infection, but this hypothesis has been difficult to test owing to the lack of a permissive in vivo model of HAdV infection. Here we established a humanized mouse model that reproduces features of acute and persistent HAdV infection. In this model, acute infection correlated with high mortality, weight loss, liver pathology, and expression of viral proteins in several organs. In contrast, persistent infection was asymptomatic and led to establishment of HAdV-specific adaptive immunity and expression of early viral genes exclusively in the bone marrow. These findings validate the use of humanized mice to study acute and persistent HAdV infection and strongly suggest the presence of cellular reservoirs in the bone marrow.
- Subjects :
- 0301 basic medicine
030106 microbiology
Mice, Transgenic
Viremia
Adaptive Immunity
Biology
Adenovirus Infections, Human
Immunocompromised Host
Mice
03 medical and health sciences
Immune system
Bone Marrow
medicine
Animals
Humans
Immunology and Allergy
Adenovirus infection
Asymptomatic Infections
Adenoviruses, Human
virus diseases
Viral Load
medicine.disease
Acquired immune system
Virology
eye diseases
Disease Models, Animal
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Liver
Acute Disease
DNA, Viral
Immunology
Humanized mouse
Bone marrow
Viral hepatitis
Viral load
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 215
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....27f76b59cdcdbdea9050236d3e81d1d5