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Progesterone and breast
- Source :
- Best Practice & Research Clinical Obstetrics & Gynaecology. 69:85-94
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Progesterone (Pg) is a pregnancy-related hormone that prepares the endometrium for the implantation of the fertilized zygote and suppresses myometrial contractility for the maintenance of pregnancy. At high concentrations, it acts as a natural immunosuppressant avoiding the rejection of a half allogeneic foetus. It is the precursor of many other related steroid hormones, but what is its role in the human breast? In this chapter, we will discuss some aspects related to Pg and its role in breast development and in the neoplastic disease. Understanding the mechanisms related to Pginduced effects in the normal and neoplastic mammary gland will light the way to exploit this hormone signalling pathway therapeutically. We will introduce some aspects of the effects of progestins in normal breast development, breast cancer risk and in neoplastic growth, and we will describe ongoing clinical trials in breast cancer using progestins or antiprogestins. Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
- Subjects :
- 0301 basic medicine
PROGESTERONE RECEPTOR ISOFORMS
Mammary gland
Breast Neoplasms
Endometrium
BREAST
Ciencias Biológicas
03 medical and health sciences
0302 clinical medicine
Breast cancer
Biología Celular, Microbiología
Pregnancy
BREAST CANCER
Progesterone receptor
medicine
Humans
Breast
skin and connective tissue diseases
Progesterone
Breast development
Fetus
PROGESTINS
Zygote
business.industry
Obstetrics and Gynecology
PROGESTERONE
General Medicine
medicine.disease
Hormones
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer research
Female
Progestins
Receptors, Progesterone
business
CIENCIAS NATURALES Y EXACTAS
Hormone
Subjects
Details
- ISSN :
- 15216934
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Best Practice & Research Clinical Obstetrics & Gynaecology
- Accession number :
- edsair.doi.dedup.....27f343fe82e889b20a50d9690ce98107