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Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
- Source :
- Biochemical and Biophysical Research Communications
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and Circetidae mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection.
- Subjects :
- Models, Molecular
0301 basic medicine
viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia, Viral
Biophysics
Sequence alignment
Peptidyl-Dipeptidase A
Biochemistry
Chinese hamster
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Animals
Humans
Amino Acid Sequence
Homology modeling
skin and connective tissue diseases
Receptor
Pandemics
Molecular Biology
Peptide sequence
Mammals
Genetics
biology
SARS-CoV-2
fungi
Pangolin
COVID-19
Cell Biology
biology.organism_classification
respiratory tract diseases
body regions
Viral Tropism
030104 developmental biology
030220 oncology & carcinogenesis
Spike Glycoprotein, Coronavirus
Tissue tropism
Angiotensin-Converting Enzyme 2
Coronavirus Infections
Sequence Alignment
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 526
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....27d87e62a1baac105d9f8b8f3db0f783
- Full Text :
- https://doi.org/10.1016/j.bbrc.2020.03.047