Back to Search
Start Over
The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies
- Source :
- Science. 288:339-344
- Publication Year :
- 2000
- Publisher :
- American Association for the Advancement of Science (AAAS), 2000.
-
Abstract
- The mechanisms by which hepatitis C virus (HCV) induces chronic infection in the vast majority of infected individuals are unknown. Sequences within the HCV E1 and E2 envelope genes were analyzed during the acute phase of hepatitis C in 12 patients with different clinical outcomes. Acute resolving hepatitis was associated with relative evolutionary stasis of the heterogeneous viral population (quasispecies), whereas progressing hepatitis correlated with genetic evolution of HCV. Consistent with the hypothesis of selective pressure by the host immune system, the sequence changes occurred almost exclusively within the hypervariable region 1 of the E2 gene and were temporally correlated with antibody seroconversion. These data indicate that the evolutionary dynamics of the HCV quasispecies during the acute phase of hepatitis C predict whether the infection will resolve or become chronic.
- Subjects :
- Adult
Male
Time Factors
Genes, Viral
Hepatitis C virus
Hepacivirus
Molecular Sequence Data
Population
Viral quasispecies
Antibodies, Viral
Virus Replication
medicine.disease_cause
Virus
Evolution, Molecular
Viral Envelope Proteins
medicine
Humans
Prospective Studies
Selection, Genetic
Seroconversion
education
Phylogeny
Aged
Hepatitis
education.field_of_study
Multidisciplinary
biology
Genetic Variation
Hepatitis C
Hepatitis C Antibodies
Hepatitis C, Chronic
Middle Aged
medicine.disease
biology.organism_classification
Virology
Acute Disease
Immunology
Disease Progression
Female
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 288
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....27d6a80541240106c0192df2bf83a0c1