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Pravastatin in vivo reduces mononuclear cell migration through endothelial monolayers
- Source :
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 27(4)
- Publication Year :
- 2006
-
Abstract
- The objective was to evaluate pravastatin modulation on peripheral blood mononuclear cell (PBMC) migration across endothelial monolayers. Eleven hypercholesterolaemic patients were treated with pravastatin 20 mg/day. At baseline (T0), after 40 days (T40) and after 6 months (T 6 months) of treatment total serum cholesterol, low-density lipoprotein (LDL), high-density lipoprotein, triglycerides, C-reactive protein, as well as tumour necrosis factor-alpha (TNF-alpha) and metalloproteinases-9 plasma levels were evaluated. At the same time points the effect of pravastatin on migration of PBMCs through a monolayer of murine brain endothelial cells was studied both in basal conditions and after endothelial stimulation with recombinant mouse TNF-alpha 10 ng/ml for 24 h. Seven volunteers were used as healthy controls. Significant decreases in total cholesterol, LDL and triglycerides as well as inhibition of transmigration were observed. PBMCs transmigration in patients prior to pravastatin therapy was higher than in healthy controls. These results suggest that pravastatin could be of benefit in a spectrum of diseases characterised by extravasation of PBMCs into the central nervous system.
- Subjects :
- Male
medicine.medical_specialty
Necrosis
Time Factors
Hypercholesterolemia
Inflammation
Enzyme-Linked Immunosorbent Assay
Dermatology
Peripheral blood mononuclear cell
In vivo
Cell Movement
Internal medicine
medicine
Humans
Endothelium
Aged
Pravastatin
business.industry
Tumor Necrosis Factor-alpha
Anticholesteremic Agents
General Medicine
Middle Aged
Extravasation
Psychiatry and Mental health
Endocrinology
Matrix Metalloproteinase 9
Immunology
Leukocytes, Mononuclear
lipids (amino acids, peptides, and proteins)
Female
Neurology (clinical)
medicine.symptom
business
Mononuclear cell migration
Lipoprotein
medicine.drug
Subjects
Details
- ISSN :
- 15901874
- Volume :
- 27
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....27d07c0aa2388e4e84d1ad62199a99c1